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May 13, 2022 10:00 am

Promising Early Results From Largest-Ever Trial Testing LSD For Anxiety

Biopharmaceutical company MindMed has announced the first topline data from a novel Phase 2 trial testing high doses of LSD as a treatment for anxiety. The results indicate one to two LSD sessions can generate rapid and sustained reductions to anxiety, however, significantly larger trials will be needed to validate these findings. New Atlas reports: This new trial was conducted at University Hospital Basel in Switzerland. The trial was randomized, and placebo-controlled with a crossover design enrolling 46 participants. The participants completed two high-dose (200-microgram) LSD sessions, six weeks apart. The primary endpoint was a reduction in anxiety 16 weeks after the second LSD session, as measured on a scale called STAI (State-Trait Anxiety Inventory), a common test used to quantify anxiety. The data revealed by MindMed indicates 65 percent (13 out of 20) patients in the LSD group demonstrated a clinically significant reduction in STAI scores of more than 30 percent. Only nine percent of the placebo group (two out of 22) showed similar clinical improvements. The results indicate the treatment was generally safe with only mild adverse effects reported by most subjects. The announcement did report one serious adverse treatment event during an LSD session described as "acute transient anxiety and delusions." This subject required sedatives but no long-term adverse effects were noted. [...] MindMed is now beginning a Phase 2b trial to expand on these findings and further explore LSD as a treatment for anxiety disorders.

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