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May 3, 2022 11:30 pm

Deadly Venom From Spiders and Snakes May Cure What Ails You

Efforts to tease apart the vast swarm of proteins in venom -- a field called venomics -- have burgeoned in recent years, leading to important drug discoveries. From a report: In a small room in a building at the Arizona-Sonora Desert Museum, the invertebrate keeper, Emma Califf, lifts up a rock in a plastic box. "This is one of our desert hairies," she said, exposing a three-inch-long scorpion, its tail arced over its back. "The largest scorpion in North America." This captive hairy, along with a swarm of inch-long bark scorpions in another box, and two dozen rattlesnakes of varying species and sub- species across the hall, are kept here for the coin of the realm: their venom. Efforts to tease apart the vast swarm of proteins in venom -- a field called venomics -- have burgeoned in recent years, and the growing catalog of compounds has led to a number of drug discoveries. As the components of these natural toxins continue to be assayed by evolving technologies, the number of promising molecules is also growing. "A century ago we thought venom had three or four components, and now we know just one type of venom can have thousands," said Leslie V. Boyer, a professor emeritus of pathology at the University of Arizona. "Things are accelerating because a small number of very good laboratories have been pumping out information that everyone else can now use to make discoveries." She added, "There's a pharmacopoeia out there waiting to be explored." It is a striking case of modern-day scientific alchemy: The most highly evolved of natural poisons on the planet are creating a number of effective medicines with the potential for many more. One of the most promising venom-derived drugs to date comes from the deadly Fraser Island funnel web spider of Australia, which halts cell death after a heart attack. Blood flow to the heart is reduced after a heart attack, which makes the cell environment more acidic and leads to cell death. The drug, a protein called Hi1A, is scheduled for clinical trials next year. In the lab, it was tested on the cells of beating human hearts. It was found to block their ability to sense acid, "so the death message is blocked, cell death is reduced, and we see improved heart cell survival," said Nathan Palpant, a researcher at the University of Queensland in Australia who helped make the discovery.

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