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January 27, 2022 01:00 pm

Frogs Without Legs Regrow Leglike Limbs In New Experiment

An anonymous reader quotes a report from The New York Times: African clawed frogs are masters of putting themselves back together, handily regenerating lost tails and hind limbs, when they are tadpoles. But these powers dim with maturity. Wait for an adult frog to regrow a lopped-off limb and you'll see only a tapered spike, more like a talon than a leg. Now, a group of scientists have found a way to harness the adult frog's own cells to regrow an imperfect but functional limb. The researchers placed a silicone cap laden with a mixture of regenerative drugs onto an amputation wound for 24 hours. Over the next 18 months, the frogs gradually regrew what was lost, forming a new leglike structure with nerves, muscles, bones and even toelike projections. The researchers describe this approach, which builds on earlier research, in a paper published Wednesday in the journal Science Advances. The process could guide future research on limb regeneration in humans, but it will be challenging to replicate the results in mammals. "It was a total surprise," Nirosha Murugan, a researcher at Algoma University in Ontario, Canada, and an author of the paper, said of the complexity of the regrown limb. "I didn't think we would get the patterning that we did." "It's not a full limb that's regrown," said Kelly Tseng, a biologist studying regeneration at the University of Nevada, Las Vegas, who was not involved with the research. "But it's certainly a robust response." "It is particularly promising that only a daylong treatment can have such a positive effect on an adult animal," Can Aztekin, a researcher studying limb regeneration at the Swiss Federal Institute of Technology in Lausanne who was not involved with the research, wrote in an email.

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