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March 24, 2021 11:20 pm

Researchers Found a Way To Send Tiny Robots Into Mouse Brains

An anonymous reader quotes a report from Gizmodo: In a mind-bending development, a team of researchers in China have managed to treat brain tumors in mice by delivering drugs to the tissues using microscopic robots. The robots jumped from the mice's bloodstreams into their brains by being coated in E. coli, which tricked the rodents' immune systems into attacking them, absorbing the robots and the cancer-fighting drugs in the process. The team's research was published today in the journal Science Robotics. It comes on the heels of previous research by members of the same team, which saw liquid-coated nanorobots remotely propelled through the jelly-like fluid of the eye. Besides being an obvious recipe for an episode of "The Magic School Bus," the research had obvious applications for ophthalmological research and medical treatments. The crafts are magnetic, and the researchers use a rotating magnetic field to pull them around remotely. On microscales -- we're talking incremental movements about 1% the width of a hair -- the researchers were able to make the hybrid bio-bots wend paths like in the video game Snake. They're dubbed "neutrobots" because they infiltrate the brain in the casing of neutrophils, a type of white blood cell. It ultimately took Wu's team eight years to actualize the microscopic robot swarms capable of bridging the gap between the rodent bloodstream in the animal's tail, where the bots were injected, and its brain, where gliomas -- tumors that emerge from the brain's glial cells -- resided. Part of the issue is that the mice's white blood cells didn't dig the flavor of the magnetic robots. To overcome that issue, Wu's team coated the bots in bits of E. coli membrane, which the white blood cells easily recognize as a unwelcome invader. That made the robots much more palatable, and the white blood cells enveloped them. From inside those cells, the robots were then able to roll the cells toward the brain; a Trojan horse for the 21st century (in this case, one that benefits the residents of Troy). The neutrobots made it into the brains and were able to deliver the drug directly to the targeted tumors.

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