Sources Contact Advanced Search Tutorials

An Interest In:

Web News this Week

Search Archive

Some of Our Sources

View All Sources

Help Webnuz

Referal links:

March 20, 2020 09:30 pm

What We Know So Far About SARS-CoV-2

We've known about SARS-CoV-2 for only three months, but scientists can make some educated guesses about where it came from and why it's behaving in such an extreme way. From a report: The structure of the virus provides some clues about its success. In shape, it's essentially a spiky ball. Those spikes recognize and stick to a protein called ACE2, which is found on the surface of our cells: This is the first step to an infection. The exact contours of SARS-CoV-2's spikes allow it to stick far more strongly to ACE2 than SARS-classic did, and "it's likely that this is really crucial for person-to-person transmission," says Angela Rasmussen of Columbia University. In general terms, the tighter the bond, the less virus required to start an infection. There's another important feature. Coronavirus spikes consist of two connected halves, and the spike activates when those halves are separated; only then can the virus enter a host cell. In SARS-classic, this separation happens with some difficulty. But in SARS-CoV-2, the bridge that connects the two halves can be easily cut by an enzyme called furin, which is made by human cells and -- crucially -- is found across many tissues. "This is probably important for some of the really unusual things we see in this virus," says Kristian Andersen of Scripps Research Translational Institute. Further reading: How the Coronavirus Could Take Over Your Body (Before You Ever Feel It)

Slashdot

Slashdot was originally created in September of 1997 by Rob "CmdrTaco" Malda. Today it is owned by Geeknet, Inc..

More About this Source Visit Slashdot