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April 16, 2019 10:00 am

Researchers 3D-Print Heart From Human Patient's Cells

Researchers have 3D-printed a heart using a patient's cells, providing hope that the technique could be used to heal hearts or engineer new ones for transplants. "This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers," Professor Tal Dvir of Tel Aviv University's School of Molecular Cell Biology and Biotechnology said in a statement. Dvir is senior author of the research, published Monday in the journal Advanced Science. CNN reports: The process of printing the heart involved a biopsy of the fatty tissue that surrounds abdominal organs. Researchers separated the cells in the tissue from the rest of the contents, namely the extracellular matrix linking the cells. The cells were reprogrammed to become stem cells with the ability to differentiate into heart cells; the matrix was processed into a personalized hydrogel that served as the printing "ink." The cells and hydrogel were first used to create heart patches with blood vessels and, from there, an entire heart. Next, the researchers plan to train the hearts to behave like hearts, Dvir explained. "The cells need to form a pumping ability; they can currently contract, but we need them to work together." If researchers are successful, they plan to transplant the 3D-printed heart in animal models and, after that, humans.

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