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October 6, 2018 03:30 am

Humans Having Sex With Neanderthals Gave Us Protection Against Ancient Epidemics

An anonymous reader quotes a report from ScienceAlert: A new study argues that we have Neanderthals to thank for helping us cope with the viral tides we encountered as we marched around the globe. Stanford University researchers have identified DNA sequences that evolved in our ancient cousins can produce antivirus proteins, which more than likely gave some human populations the edge they needed to survive. Roughly 1 percent of our genome's coding was written in Neanderthal populations. But this is a broad average -- many families with African ancestry have zero, for instance, while other populations boast as much as 2 percent or more. So the question is how much of this difference comes down to the random drift of DNA being passed on around the globe, and how much is due to natural selection giving those with Neanderthal genes an advantage? To build a case one way or another, the Stanford researchers put together a list of just over 4,500 virus-interacting proteins (VIP) made by our genome. These were all matched against a database of Neanderthal DNA that could be found in modern East Asian and European human populations, providing 152 VIP genes shared by both groups of human. Interestingly, all of these VIP genes were of a variety that interacted with RNA viruses -- pathogens that include influenza A, hepatitis C, and HIV. This isn't to say these viruses were problems for ancient humans, but rather that similar RNA viruses were more than likely prevalent enough to shape our evolution. The discovery supports a view of genetic exchange described as the 'poison-antidote' model.

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