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August 4, 2018 01:40 am

Air Pollution Linked To Changes In Heart Structure, Study Shows

Researchers say air pollution is linked to changes in the structure of the heart of the sort seen in early stages of heart failure. "The findings could help explain the increased number of deaths seen in areas with high levels of dirty air," reports The Guardian. From the report: "What we don't know is what is the mechanism behind it, why is air pollution leading to increased risk of heart attack and stroke?" said Dr Nay Aung, a cardiologist at Queen Mary University of London and first author of the research. The latest study helps to unpick the conundrum. Writing in the journal Circulation, Aung and colleagues report that they found exposure to nitrogen dioxide and fine particulate matter, known as PM2.5 and PM10 particles, is linked to an increase in the size of two of the chambers of the heart, the left and right ventricle. PM particles are commonly emitted by motor vehicles, among other sources. The authors add that similar changes can affect the performance of the heart and are often seen before heart failure takes hold. The team used data from almost 4,000 volunteers who were part of a wider research effort known as the UK Biobank. These participants were aged between 40 and 69 years old, had been at the same address for the whole study, and were free from cardiovascular disease at the outset. Crucially, their data included cardiac MRI scans, which offer detailed images of the structure and function of the heart. The study also involved estimates of the outdoor concentrations of different pollutants at participants' home addresses at about five years prior to the scan. After controlling for factors including age, sex, income and smoking history, the team found that higher exposure to PM2.5 particles, PM10 particles and nitrogen dioxide were each linked to a greater volume of both the right and left ventricles after they had filled with blood.

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