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June 11, 2018 08:50 pm

A Serious New Hurdle For CRISPR: Edited Cells Might Cause Cancer, Find Two Studies

Editing cell genomes with CRISPR-Cas9 might increase the risk of developing cancer, two studies published Monday warn. From a report: Editing cells' genomes with CRISPR-Cas9 might increase the risk that the altered cells, intended to treat disease, will trigger cancer, two studies published on Monday warn -- a potential game-changer for the companies developing CRISPR-based therapies. In the studies, published in Nature Medicine, scientists found that cells whose genomes are successfully edited by CRISPR-Cas9 have the potential to seed tumors inside a patient. That could make some CRISPR'd cells ticking time bombs, according to researchers from Sweden's Karolinska Institute and, separately, Novartis. CRISPR has already dodged two potentially fatal bullets -- a 2017 claim that it causes sky-high numbers of off-target effects was retracted in March, and a report of human immunity to Cas9 was largely shrugged off as solvable. But experts are taking the cancer-risk finding seriously.

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Original Link: http://rss.slashdot.org/~r/Slashdot/slashdot/~3/s4NdGOL9Qww/a-serious-new-hurdle-for-crispr-edited-cells-might-cause-cancer-find-two-studies

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