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November 2, 2017 02:00 pm

Scientists Have Mathematical Proof That It's Impossible To Stop Aging

An anonymous reader quotes a report from Science Alert: Mathematically speaking, multicellular organisms like us will always have to deal with a cellular competition where only one side will win. And ultimately, that means our vitality will always come out as the loser. We have a pair of researchers from the University of Arizona to blame for this depressing conclusion, who crunched the numbers on a hypothesis involving the weeding out of unfit cells and found it amounted to a catch-22 situation. Aging -- and all of the biological changes that come with it -- is more or less the result of cells slowing down and losing their functions. But what if there was a way to encourage the more active cells to stick around at the expense of their sluggish siblings? Surely if we knocked off those old cells we could keep making pigments and collagen a little longer. Researchers have pinned hopes on reversing the inevitable decay of biochemistry by repairing DNA or extending the shrinking bits of chromosome called telomeres, for example. While it's good in theory, there is a catch. Another feature of aging is a number of cells start to populate like there's no tomorrow, reproducing in uncontrolled ways that look too close to cancer for comfort. According to the researchers, this means we're damned either way. The way we grow old poses something of a mystery. If replicating biology is good enough to continue for generations, why do our own cells wind down after just a few decades? A simple answer is evolution isn't strong enough to weed out genes that only cause us grief after we've popped out a few offspring. But this model of aging adds a new element to the existing hypothesis -- even if evolution did select for eternal youth, competition inside our own bodies would see us to an inevitable grave. In other words, since multicellular organisms are the cumulative effect of bunches of cooperating cells, we logically can't have it both ways -- if you clear the way for 'younger' cells to keep your skin baby-smooth, you're just asking for the big C. The findings have been published in the journal Proceedings of the National Academy of Sciences.

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