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July 14, 2017 12:00 pm

Biologists Use Gene Editing To Store Movies In DNA

New submitter elmohound writes: A recent paper in Nature describes how gene editing was used to store a digital movie into a bacterial population. The choice of subject is a nice hommage to Muybridge's 1887 photos. From a report via Scientific American: "The technical achievement, reported on July 12 in Nature, is a step towards creating cellular recording systems that are capable of encoding a series of events, says Seth Shipman, a synthetic biologist at Harvard Medical School in Boston, Massachusetts. To develop such a system, however, his team would need to establish a method for recording hundreds of events in a cell. Shipman and his colleagues, including Harvard geneticist George Church, harnessed the CRISPR-Cas immune system best known for enabling researchers to alter genomes with relative ease and accuracy. Shipman's team exploited the ability to capture snippets of DNA from invading viruses and store them in an organized array in the host genome. In nature, those snippets then target an enzyme to slice up the invader's DNA. The team designed its system so that these snippets corresponded to pixels in an image. The researchers encoded the shading of each pixel -- along with a barcode that indicated its position in the image -- into 33 DNA letters. Each frame of the movie consisted of 104 of these DNA fragments." You can view the movie here, which consists of five frames adapted from Muybridge's Human and Animal Locomotion series.

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